Les données cliniques ont montré une variation significativement plus faible du taux de lactate dans les cœurs avec un temps ischémique prolongé et préservés à 10°C1
l’indice cardiaque était plus élevé dans les cœurs préservés à 10 °C à 24 et 72 heures après la transplantation malgré des scores inotropes vasoactifs similaires1
Publications de résultats cliniques
Les études ci-dessous n’ont peut-être pas utilisé la version commerciale de X°Port. Veuillez consulter les documents et les méthodes de chaque étude pour plus de détails.
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Cooler Isn’t Better: 10°C Storage Outperforms 4-8°C Preservation with Lower Primary Graft Dysfunction and Improved Outcomes
ISHLT 2026 Annual Meeting & Scientific Sessions. Poster.
A. Williams, B. Lima, A. Ahmad, A. Benkert, S. Bommareddi, J. Trahanas, et al.
10°C SCS may enhance myocardial ischemic tolerance and improve post-transplant outcomes versus 4-8°C SCS, supporting its potential to redefine cardiac allograft preservation standards.
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Enhanced Myocardial Performance After Heart Transplantation with 10°C Static Cold Storage: A Real-Time Hemodynamic Analysis
ISHLT 2026 Annual Meeting & Scientific Sessions. Poster.
A. Ahmad, C. Wang, M. Petrovic, J. Trahanas, S. Bommareddi, T. Absi, et al.
10°C preservation may mitigate ischemic injury and enhance post-transplant myocardial performance.
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10°C Storage Preserves Metabolic Reserve and Reduces Oxygen Debt in Heart Transplantation
ISHLT 2026 Annual Meeting & Scientific Sessions. Presentation.
A. Ahmad, C. Wang, M. Petrovic, J. Trahanas, S. Bommareddi, T. Absi, et al.
10°C SCS reduces O₂ER burden even in higher-risk grafts, supporting improved metabolic preservation and reduced ischemia-reperfusion injury compared to ice.
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Tick Tock Goes the Clock: Normothermic Machine Perfusion versus Static Cold Storage at 10°C for Extended Preservation of Cardiac Allografts
ISHLT 2026 Annual Meeting & Scientific Sessions. Presentation.
S. Patlolla, A. Ahmad, C. Wang, M. Petrovic, B. Lima, S. Bommareddi, et al.
10°C and NMP appear to yield similar post-transplant survival, with a non-significant trend towards higher incidence of severe primary graft dysfunction in the NMP group (9.4% vs 2.6%; p=0.32)
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The Fall of the Machines: 10°C Static Storage Provides Superior Myocardial Preservation Compared to Normothermic Machine Perfusion
ISHLT 2026 Annual Meeting & Scientific Sessions. Poster.
A. Williams, B. Lima, A. Ahmad, A. Bankert, J. Trahanas, S. Bommareddi, et al.
Overall, 10°C SCS demonstrated superior myocardial protection and early graft recovery compared to NMP, even in prolonged ischemic time.
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Out of the Ice Age: Preservation of Cardiac Allografts with a Reusable 10°C Cooler
Journal of Thoracic and Cardiovascular Surgery. 2024;21:197-209.
Trahanas, J.M., Harris, T., Petrovic, M., Dreher, A., Pasrija, C., Devries, S., Bommareddi, S., Lima, B., Wang, C., Cortelli, M., Fortier, A., Tracy, K., Simonds, E., Keck, C., Scholl, S., Siddiqi, H., Schlendorf, K., Bachetta, M., Shah, A.
Heart preservation at 10°C resulted in excellent allograft function, with better cardiac index and lower lactate profiles in allografts with extended ischemic times than controls preserved on ice.
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The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017; Focus Theme: Allograft ischemic time
Journal of Heart and Lung Transplantation. 2017;36(10):1037-1046.
Lund, L.H., Khush, K.K., Cherikh, W.S., Goldfarb, S., Kucheryavaya, A.Y., Levvey, B.J., Meiser, B., Rossano, J.W., Chambers, D.C., Yusen, R.D., Stehlik, J., International Society for Heart and Lung Transplantation.
This 2017 ISHLT Focus Theme on allograft ischemic time explores the associations between recipient and donor characteristics and allograft ischemic time, and the potential role of allograft ischemic time in affecting outcomes.
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Validation of the International Society for Heart and Lung Transplantation primary graft dysfunction instrument in heart transplantation
Journal Heart Lung Transplantation. 2019;38(3):260–6
Foroutan, F., Alba, A.C., Stein, M., Krakovsky, J., Chien, K.G.W., Chih, S., Guyatt, G., Ross, H.
The ISHLT LV-PGD classification convincingly identifies a substantial increase in the risk of death at 1 year, and an increased gradient of risk, in those with moderate or severe LV-PGD. In this cohort study, PGD rate was shown to be 17%.
Cet appareil est réservé à la vente par ou sur ordonnance d’un professionnel de la santé agréé. Veuillez consulter les instructions d’utilisation de votre pays. Cet appareil n’est actuellement pas autorisé à être utilisé ou vendu pour la préservation cardiaque aux États-Unis. Contactez Traferox pour plus d’informations.
- Trahanas JM., Harris T, Petrovic M, et al. 2025. Out of the Ice Age: Preservation of Cardiac Allografts with a Reusable 10°C Cooler. JTCVS Open, S2666-2736(24)00226-2 ↩︎