La conservation et le transport à 10°C constituent un point tournant
Les recherches précliniques et cliniques sur la conservation des organes à 10°C ont produit des résultats prometteurs.
Conservation optimisée. Durée prolongée.
- Conservation prolongée démontrée dans une étude multicentrique Une étude multicentrique a montré que la durée de conservation pouvait être
doublée sans augmentation du taux de complications1 - Amélioration de la santé mitochondriale grâce à la conservation à 10°C
Les poumons conservés à 10 °C ont une meilleure santé mitochondriale et une fonction préservée.2
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Les études ci-dessous n’ont peut-être pas utilisé la version commerciale de X°Port. Veuillez consulter les documents et les méthodes de chaque étude pour plus de détails.
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Extension of Cold Static Donor Lung Preservation at 10°C
New England Journal of Medicine Evidence. 2023;2(6)
Ali, A., Hoetzenecker, K., Campo-Cañaveral de la Cruz, J., Schwarz, S., Barturen, M.G., Tomlinson, G., Yeung, J., Donahoe, L., Yasufuku, K., Pierre, A. and de Perrot, M.
Lung preservation at 10°C allows for longer preservation times and is safe and effective, with no significant differences from lungs stored for half the time.
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Prolonged Preservation of up to 24h at 10°C does not impact outcomes after lung transplantation
Annals of Surgery. 2025;281(4), pp.664-670
Hoetzenecker, K., Ali, A., Campo-Cañaveral de la Cruz, J., Schwarz, S., Crowley Carrasco, S., Romero Roman, A., Aladaileh, M., Benazzo, A., Jaksch, P., Wakeam, E., Aversa, M., Keshavjee, S., Cypel, M.
Prolonged static preservation of donor lungs at 10°C for up to 24 hours is safe and does not impair short-intermediate outcomes after lung transplantation.
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Static Lung Storage at 10°C Maintains Mitochondrial Health and Preserves Donor Organ Function
Science Translational Medicine. 2021;13(611)
Ali, A., Wang, A., Ribeiro, R.V., Beroncal, E.L., Baciu, C., Galasso, M., Gomes, B., Mariscal, A., Hough, O., Brambate, E. and Abdelnour-Berchtold, E.
10°C lung preservation results in better mitochondrial health compared to 4°C controls, resulting in better lung function.
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Evaluation of 10°C as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model
The Journal of Heart and Lung Transplantation. 2022;41(12), pp.1679-1688
Abdelnour-Berchtold, E., Ali, A., Baciu, C., Beroncal, E.L., Wang, A., Hough, O., Kawashima, M., Chen, M., Zhang, Y., Liu, M. and Waddell, T.
10°C demonstrated as a potentially superior storage temperature for injured donor lungs in a pig model when compared to the current clinical standard (4°C) and immediate transplantation.
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Overcoming the limits of lung transplantation: 10°C static cold preservation
Archivos de Bronconeumologia. 2023;59(5), pp.282-283
Campo-Cañaveral de la Cruz, J., Barturen, M.G., Ali, A., Hoetzenecker, K. and Cypel, M.
Donor lung preservation methods are moving forward at a continuous and exciting pace, which will significantly change the entire field of lung transplantation
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Donor Lung Preservation at 10°C: Clinical and Logistical Impact
Archivos de Bronconeumología. 2024;60(6), pp.336-343.
Barturen, M.G., Hernández, R.L., Berrocal, A.R., Redondo, M.P., Lozano, N.G., López, J.M., Vicente, A.R., Román, A.R., Mejía, L.H., Carrasco, S.C., Gómez de Antonio, D., Naranjo Gómez, J.M., Córdoba Peláez, M., Novoa, N.M., Campo-Cañaveral de la Cruz, J.L
Preservation at 10°C may represent a safe and feasible strategy to intentionally prolong the CIT. Extending the CIT at 10°C may allow for semi-elective LTx and improve logistics with similar outcomes compared to the current standard preservation methods.
La PPEV permet d’optimiser les organes de donneurs disponibles
Augmentation du volume de transplantation. Réduction de
la mortalité.
- Augmentation significative de la disponibilité des poumons des donneurs1
Des études ont montré une augmentation du nombre de transplantations pulmonaires lorsque la PPEV est utilisé pour l’évaluation des poumons de donneur, avec des résultats comparables à ceux des patients ayant reçu des poumons ne nécessitant pas d’évaluation avec la PPEV. - L’augmentation du volume de transplantation améliore l’efficacité et les résultats2
Un taux de transplantation plus élevé a été associé à des temps d’attente réduits, des séjours plus courts en unité de soins intensifs et à de meilleurs résultats à long terme pour les patients, ce qui se traduit par des économies de coûts significatives
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1,000 Cases of Ex Vivo Lung Perfusion for Lung Transplantation: A Single Centre Experience
The Journal of Thoracic and Cardiovascular Surgery. 2025.
Keshavjee, S., Sage, A.T., Borrillo, T.., Yeung, J.C., Piyasena, D., Wakeam, E., Donahoe, L., Waddell, T.K., de Perrot, M., Pierre, A., Balachandran, S., Ghany, R., Ali, A., Yasufuku, K., Cypel, M.
This study presents the largest single-centre EVLP experience to date, highlighting how EVLP has transformed clinical lung transplantation with expansion of donor access, program growth, and the safe use of extended criteria donor lungs.
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Normothermic ex vivo lung perfusion in clinical lung transplantation
New England Journal of Medicine. 2011;364(15), 1431-1440
Cypel, M., Yeung, J., Liu, M., Anraku, M., Chen, F., Karolak, W., Sato, M., Laratta, J., Azad, S., Madonik, M., Chow, C., Chaparro, C., Hutcheon, M., Singer, L., Slutsky, A., Yasufuku, K., de Perrot, M., Pierre, A., Waddell, T., Keshavjee, S.
Transplantation of high-risk donor lungs that were physiologically stable during 4 hours of ex vivo perfusion led to results similar to those obtained with conventionally selected lungs.
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Evaluating the impact of ex vivo lung perfusion on organ transplantation: a retrospective cohort study
Annals of Surgery. 2023;278(2), pp.288-296
Peel, J.K., Pullenayegum, E.M., Naimark, D., Aversa, M., Liu, M., Del Sorbo, L., Barrett, K., Sander, B. and Keshavjee, S.
A significant increase in organ transplantation was observed since EVLP was introduced into practice, predominantly from increased acceptance of donation after circulatory death and extended-criteria lungs.
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Determining the impact of ex-vivo lung perfusion on hospital costs for lung transplantation: A retrospective cohort study
The Journal of Heart and Lung Transplantation. 2023;42(3), pp.356-367
Peel, J.K., Keshavjee, S., Naimark, D., Liu, M., Del Sorbo, L., Cypel, M., Barrett, K., Pullenayegum, E.M. and Sander, B.
EVLP availability was associated with faster progression to transplantation at no significant marginal cost in this single-center study.
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Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion
JAMA Surgery. 2019;154(12), pp.1143-1150
Divithotawela, C., Cypel, M., Martinu, T., Singer, L.G., Binnie, M., Chow, C.W., Chaparro, C., Waddell, T.K., de Perrot, M., Pierre, A. and Yasufuku, K.
Use of EVLP-treated lungs led to an increase in the number of patients undergoing transplantation, with comparable long-term outcomes.
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Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study
The Lancet Respiratory Medicine. 2017;5(2), pp.119-124
Yeung, J.C., Krueger, T., Yasufuku, K., de Perrot, M., Pierre, A.F., Waddell, T.K., Singer, L.G., Keshavjee, S. and Cypel, M.
Extension of clinical lung preservation times might allow for more transplantations to be done as a result of improved facilitation and increased flexibility around timing of lung transplantation operations.
- Ali, A., Hoetzenecker, K., Luis Campo-Cañaveral de la Cruz, J., Schwarz, S., Barturen, M.G., Tomlinson, G., Yeung, J., Donahoe, L., Yasufuku, K., Pierre, A., de Perrot, M., Waddell, T.K., Keshavjee, S., Cypel, M.. Extension of Cold Static Donor Lung Preservation at 10°C. NEJM Evid. 2023 Jun;2(6):EVIDoa2300008. doi: 10.1056/EVIDoa2300008. Epub 2023 Apr 20. PMID: 38320127. ↩︎
- Ali, A., Wang, A., Ribeiro, R.V.P., Beroncal, E.L., Baciu, C., Galasso, M., Gomes, B., Mariscal, A., Hough, O., Brambate, E., Abdelnour-Berchtold, E., Michaelsen, V., Zhang, Y., Gazzalle, A., Fan, E., Brochard, L., Yeung, J., Waddell, T., Liu, M., Andreazza, A.C., Keshavjee, S., Cypel, M. Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function. Sci Transl Med. 2021 Sep 15;13(611):eabf7601. doi: 10.1126/scitranslmed.abf7601. Epub 2021 Sep 15. PMID: 34524862 ↩︎