Why Donor Heart Optimization Matters

When organ preservation time is limited, overcoming geographical barriers or finding the right recipient in time can be especially challenging.

Preservation and Transport Challenges

Preservation of hearts on ice is limited to 4-6 hours1

Minimal preservation time limits transport distance and creates logistical challenges

Primary graft dysfunction rates after transport on ice have been reported to be as high as 17%2

Surgical team performing a heart transplant in an operating room

Extending the window between heart procurement and transplant helps optimize logistics and allows more organs to be transplanted, ultimately leading to improved healthcare and economic outcomes.

Overcomes geographical hurdles

Optimized donor/recipient matching3

Improved organ preservation4

Improved operating room logistics3

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  1. Lund LH, Khush KK, Cherikh WS, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult heart transplantation report—2017; focus theme: allograft ischemic time. J Heart Lung Transpl 2017;36:1037-46. https://doi.org/ 10.1016/j.healun.2017.07.019 ↩︎
  2. Foroutan F, Alba AC, Stein M, et al. Validation of the International Society for Heart and Lung Transplantation primary graft dysfunction instrument in heart transplantation. J Heart lung Transplantation: Official Publication Int Soc Heart Transplantation. 2019;38(3):260–6. doi: 10.1016/j.healun.2018.12.007. ↩︎
  3. Barturen, M.G., Ali, A., Hoetzenecker, K. and Cypel, M., 2023. Overcoming the limits of lung transplantation: 10°C static cold preservation. Archivos de bronconeumologia, 59(5), pp.282-283. ↩︎
  4. Trahanas JM., Harris T, Petrovic M, et al. 2025. Out of the Ice Age: Preservatoin of Cardiac Allografts with a Reusable 10°C Cooler. JTCVS Open, S2666-2736(24)00226-2 ↩︎