Heart Preservation and Perfusion Published Evidence

Clinical data showed significantly lower lactate change in hearts with extended ischemic time preserved at 10°C1

Cardiac index score was greater in 10°C preserved hearts at 24 and 72h post-transplantation despite similar vasoactive inotrope scores1

Published Evidence

The studies below may not have used the commercial version of X°Port. Please review the materials and methods of individual studies for details.

  • Out of the Ice Age: Preservation of Cardiac Allografts with a Reusable 10°C Cooler

    Journal of Thoracic and Cardiovascular Surgery. 2024;21:197-209.

    Trahanas, J.M., Harris, T., Petrovic, M., Dreher, A., Pasrija, C., Devries, S., Bommareddi, S., Lima, B., Wang, C., Cortelli, M., Fortier, A., Tracy, K., Simonds, E., Keck, C., Scholl, S., Siddiqi, H., Schlendorf, K., Bachetta, M., Shah, A.

    Heart preservation at 10°C resulted in excellent allograft function, with better cardiac index and lower lactate profiles in allografts with extended ischemic times than controls preserved on ice.

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  • The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017; Focus Theme: Allograft ischemic time

    Journal of Heart and Lung Transplantation. 2017;36(10):1037-1046.

    Lund, L.H., Khush, K.K., Cherikh, W.S., Goldfarb, S., Kucheryavaya, A.Y., Levvey, B.J., Meiser, B., Rossano, J.W., Chambers, D.C., Yusen, R.D., Stehlik, J., International Society for Heart and Lung Transplantation.

    This 2017 ISHLT Focus Theme on allograft ischemic time explores the associations between recipient and donor characteristics and allograft ischemic time, and the potential role of allograft ischemic time in affecting outcomes.

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  • Validation of the International Society for Heart and Lung Transplantation primary graft dysfunction instrument in heart transplantation

    Journal Heart Lung Transplantation. 2019;38(3):260–6

    Foroutan, F., Alba, A.C., Stein, M., Krakovsky, J., Chien, K.G.W., Chih, S., Guyatt, G., Ross, H.

    The ISHLT LV-PGD classification convincingly identifies a substantial increase in the risk of death at 1 year, and an increased gradient of risk, in those with moderate or severe LV-PGD. In this cohort study, PGD rate was shown to be 17%.

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This device is restricted to sale by or on the order of a licensed healthcare practitioner. Please refer to the instructions for use and indications for use in your country. This device is not currently cleared for use or sale for Heart Preservation in the United States. Contact Traferox for more information.

  1. Trahanas JM., Harris T, Petrovic M, et al. 2025. Out of the Ice Age: Preservation of Cardiac Allografts with a Reusable 10°C Cooler. JTCVS Open, S2666-2736(24)00226-2 ↩︎