Lung Preservation and Perfusion Published Evidence

Preservation and Transport at 10°C is a Game Changer

Clinical and preclinical research has shown promising outcomes with organs preserved at 10°C.

Optimized preservation. Extended duration.

  • Extended Preservation Demonstrated in Multi-Centre Study
    A multi-centre study showed that preservation time could be extended to twice the typical time with no increase in complications1
  • Improved Mitochondrial Health with 10°C Preservation
    Lungs preserved at 10°C have better mitochondrial health and preserved donor organ function2

This device is restricted to sale by or on the order of a licensed health care practitioner. Please refer to the instructions for use and Indications for use in your country. Contact Traferox for more information.

The studies below may not have used the commercial version of X°Port. Please review the materials and methods of individual studies for details.

No research found.

EVLP Enables Optimization of Available Donor Organs

Increased transplant volume. Decreased mortality.

  • Significantly expanded donor lung availability1
    Studies have shown increases in the number of lung transplants when EVLP is used for donor lung assessment, with comparable outcomes to patients who received lungs that did not require assessment via EVLP.
  • Increased transplant volume drives efficiency and outcomes2
    Higher transplant rates have been linked to reduced waitlist times, shorter ICU stays, and improved long-term patient outcomes—resulting in meaningful cost savings.

  • Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion

    JAMA Surgery. 2019;154(12), pp.1143-1150

    Divithotawela, C., Cypel, M., Martinu, T., Singer, L.G., Binnie, M., Chow, C.W., Chaparro, C., Waddell, T.K., de Perrot, M., Pierre, A. and Yasufuku, K.

    Use of EVLP-treated lungs led to an increase in the number of patients undergoing transplantation, with comparable long-term outcomes.

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  • Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study

    The Lancet Respiratory Medicine. 2017;5(2), pp.119-124

    Yeung, J.C., Krueger, T., Yasufuku, K., de Perrot, M., Pierre, A.F., Waddell, T.K., Singer, L.G., Keshavjee, S. and Cypel, M.

    Extension of clinical lung preservation times might allow for more transplantations to be done as a result of improved facilitation and increased flexibility around timing of lung transplantation operations.

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  1. Ali, A., Hoetzenecker, K., Luis Campo-Cañaveral de la Cruz, J., Schwarz, S., Barturen, M.G., Tomlinson, G., Yeung, J., Donahoe, L., Yasufuku, K., Pierre, A., de Perrot, M., Waddell, T.K., Keshavjee, S., Cypel, M.. Extension of Cold Static Donor Lung Preservation at 10°C. NEJM Evid. 2023 Jun;2(6):EVIDoa2300008. doi: 10.1056/EVIDoa2300008. Epub 2023 Apr 20. PMID: 38320127. ↩︎
  2. Ali, A., Wang, A., Ribeiro, R.V.P., Beroncal, E.L., Baciu, C., Galasso, M., Gomes, B., Mariscal, A., Hough, O., Brambate, E., Abdelnour-Berchtold, E., Michaelsen, V., Zhang, Y., Gazzalle, A., Fan, E., Brochard, L., Yeung, J., Waddell, T., Liu, M., Andreazza, A.C., Keshavjee, S., Cypel, M. Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function. Sci Transl Med. 2021 Sep 15;13(611):eabf7601. doi: 10.1126/scitranslmed.abf7601. Epub 2021 Sep 15. PMID: 34524862 ↩︎